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We show that Nrf2 protein is produced postnatally by the rat choroidal tissue, and translocates in the nucleus of choroidal epithelial cells upon in vivo treatment of rat pups with DMF

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The pathological mechanism might be the dysregulation of glucose metabolism, which triggered the accumulation of epicardial adipose tissue (EAT) and free fatty acids in heart, leading to myocardial lipotoxicity, oxidative stress, and mitochondrial dysfunction [41]

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