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NICE guidelines (NG28) recommend reviewing GLP-1 treatment at around 6 months and continuing only if there has been a meaningful reduction in HbA1c (typically at least 11 mmol/mol [1%]) and weight loss of at least 3% of initial body weight
Preclinical data suggest GIP receptor engagement modulates lipid partitioning pathways and may act synergistically with GLP-1 receptor signalling in energy-balance models
Cell death: critical control points
In effect, adding prandial RAIs to the treatment regimen mimics the physiological meal-simulated insulin release, which is lost first as beta-cell function declines
Advantage: BPC-157 for gut health and digestive support
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