& Mushens, R
Whilst mild nausea, bloating, or changes in bowel habits are common, especially during dose escalation, severe or worsening symptoms warrant medical review
This is a large, carefully designed observational study not a randomised trial so it points to a promising signal rather than a proven benefit
To use the language of diet book doctors, the drug makes the body shift into a fat-burning mode (as shown by the drop in RER), which then: Feeds the system from within, making the stored fat available for oxidation, which Suppresses appetite indirectly, and Attenuates the usual energy-conserving adaptations that go with calorie-restricted diets and weight loss
While these trials used different populations and durations, the magnitude difference has driven clinicians to consider tirzepatide when patients plateau on semaglutide

It is also important to contact your doctor immediately if, while taking semaglutide, you experience: hoarseness shortness of breath difficulty swallowing a lump or swelling in the neck Indications Having certain health conditions may affect how well semaglutide works, so it is important to tell your doctor if you have any other medical problems, but especially: diabetic retinopathy depression kidney disease digestion problems type 1 diabetes type 2 diabetes (if using Wegovy) thyroid cancer diabetic ketoacidosis pancreatitis Side Effects of Wegovy Some of the mild and common side effects associated with Wegovy include: burping bloating or pain in the abdomen gas indigestion or heartburn dizziness diarrhea headache nausea vomiting constipation fatigue stomach flu These mild side effects often go away within a few days to a couple of weeks, but be sure to talk to your doctor if they become bothersome or worsen