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Typical 16-Week Titration Pre-blended CagriSema Titration (mirrors REDEFINE protocol structure) Week 14 Cagrilintide 0.25 mg Semaglutide 0.25 mg Notes Initiation: gastrointestinal tolerability is highest priority

The authors attributed the result largely to reduced energy intake driven by decreased appetite

The results are summarized in Table 3

Many researchers who think they need split dosing actually need better titration

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