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The recommendation to cycle off is based on caution, not hard evidence
Lian, G
Dietary fats and carbohydrates consumed around the administration window reduce GH release substantially
Blood 82(10 Suppl 1), 1993
Stay well hydrated to support absorption and overall energy benefits
The closest FDA-approved IGF-1 product is mecasermin (Increlex) , native recombinant human IGF-1, approved only for the long-term treatment of growth failure in pediatric patients with severe primary IGF-1 deficiency or GH gene deletion with neutralizing antibodies
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