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Perhaps the secret to GLP-1 drugs success might be hidden right there in the name

While GLP-1 therapy is effective at reducing appetite and aiding weight loss, probiotics can enhance these effects by supporting a healthy gut microbiome, improving digestion, and reducing inflammation

DAPA-HF (Dapagliflozin and Prevention of Adverse Outcomes in Heart Failure) revealed that the use of dapagliflozin in patients with New York Heart Association (NYHA) class II, III, or IV heart failure and an ejection fraction of 40% resulted in a lower risk of worsening heart failure and cardiovascular death

Electrolyte replacement becomes important if diarrhea is significant