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Vilsbll T, Agers H, Krarup T, et al

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Levels decline with age, which has prompted interest in supplementation

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Interestingly, in elderly subjects with normal BP, acute elevations of plasma insulin during hyperinsulinemic/euglycemic clamp caused vasoconstriction, accompanied by a blunted increase in norepinephrine and heart rate, as compared to young individuals, while no changes in BP were observed in either group