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Psychiatry 182 , 297306 (2025)

There are different receptors and one of them (Kappa opioid receptor or KOR) is fascinating

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No significant group differences were detected in the dorsal striatum or putamen, the other ROIs analyzed

Notably, a prescription that identifies only a patients name and drug product formulation is not sufficient to establish that the prescriber made the determination that the formulation would produce a significant difference from the commercially available drug product. According to the guidance, appropriate justification and documentation might include the following: No Dye X, patient allergy (if the comparable drug contains the dye) Liquid form, patient cant swallow tablet (if the comparable drug is a tablet) 6 mg, patient needs higher dose (if the comparable drug is only available in 5 mg dose)