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O., Tanaka, Y
(2021) SLC25A39 is necessary for mitochondrial glutathione import in mammalian cells
Moreover, the absence of reliable biomarkers to assess neuroprotection in humans further complicates progress in this field
We have shown that effective pharmacologic inhibition of GPX4 in PTC cells with direct inhibitor RSL3 induces a robust activation of ferroptosis, increased DNA damage, impaired DNA damage repair response due to reduced p-NPM1 levels, decreased cell viability and cell migration, as well as suppressed spheroid formation and viability in vitro
Compatible with all standard peptide formulations
Oxidative Medicine and Cellular Longevity, 2017 , 8416763
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