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Intact and total AMG 133 exposures more closely approximate each other in the initial phase of the study than in the terminal phase (Fig

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In short, 600 g purified latent enzyme were mixed with 50 mM sodium ascorbate, diluted to a total volume of 400 l with 100 mM sodium phosphate buffer at pH 6.0 and 600 l of a 0.5 g/l 2,2-biquinolinein glacial acetic acid solution were added

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