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Status After the Development Studies Glycemic Effect To summarize the studies undertaken with DPP-4 inhibitors as monotherapy or in combination with other glucose-lowering therapies in the years around 2010, they showed that the inhibitors reduce HbA1c by 0.50.8% (58 mmol/mol), have a low risk for hypoglycemia (except in combination with sulfonylurea), and are weight neutral

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