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(2010) 298:G60814

Unlike the C-terminal amide of Melanotan II, the free carboxylate here is titratable and carries an additional negative charge at neutral pH, so record buffer pH alongside concentration when comparing the two molecules in the same assay

Decline in PSA levels was observed in 13/16 evaluable patients, and stable disease for 6 months was seen in 41.2% of patients 143

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However, this synthetic peptide is more potent than sermorelin

Elevated insulin drives de novo lipogenesis (fat synthesis from carbohydrates), so reducing insulin through improved receptor sensitivity indirectly reduces hepatic fat accumulation