Avkhimenko Cardiovascular Therapy and Prevention.2023
Its critical to note that while some plant compounds may indirectly influence GLP-1 pathways or mimic some GLP-1 effects, they are not equivalent to pharmaceutical GLP-1 receptor agonists, Dr
Mangiferin has been shown to enhance electrical signaling in the brain and exert neuroprotective effects by reducing inflammation and oxidative stress, supporting mitochondrial function, modulating neurotransmitter activity, and preserving BDNF
A March 2026 paper published in Cell Reports Medicine by Langer, Baar, and colleagues is the most comprehensive preclinical and clinical assessment of GLP-1 medicines and skeletal muscle published to date
Of the over 17,000 patients enrolled in the SELECT trial, about 25% had heart failure, of which about one-third had HFrEF
Eur J Endocrinol 185(4):G43G67