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Accumulation of PIP 3 attracts downstream effector proteins containing PH domains, including PDK1 and mTORC2 (also called PDK2), which phosphorylate Akt (PKB) at Ser308 and Thr473, respectively, leading to full activation of Akt (74, 76)

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In children, a maintenance dose of 1.7 mg weekly may be more appropriate based on individual response

For marketed GLP-1 receptor agonists, FDA prescribing information warns clinicians to watch for possible acute pancreatitis

Availability may vary by region, pharmacy supply, and clinical program structure

Constipation: This is reported slightly more often with semaglutide, at 29% versus 27% with tirzepatide