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Even people who achieve the treatment goals with the new obesity pharmacotherapies might decide to undergo bariatric surgery to support long-term weight maintenance because either they experience weight regain on the medication or they do not have long-term access to obesity pharmacotherapy, or they prefer not to take obesity pharmacotherapy lifelong

Both agents affect appetite signaling and metabolic pathways, raising concerns about additive effects and unpredictable outcomes

Appetite Suppression: Research indicates that MT-II suppresses appetite and promotes fat loss by targeting melanocortin receptors (MC2R and MC5R) involved in lipolysis

Tirzepatide: GLP-1 and GIP receptor activation Glucose-dependent insulinotropic polypeptide was historically called gastric inhibitory polypeptide

Only slight reversible creatinine decreases at very high doses (2 mg/kg) were noted

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