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REDEFINE 1 (obesity, no diabetes) A phase 3a, 68-week, multicentre, double-blind, placebo- and active-controlled trial (NCT05567796 [10] ) enrolling 3,417 adults without diabetes with BMI 30, or 27 with at least one obesity-related complication

We propose a predisposition to tissue fragility in patients with clEDS, in particular of the gastrointestinal tract and emphasize the importance of counseling with regard to the risk of gastrointestinal complications

The Phase 2 NEJM trial showed 24.2% average body weight reduction at 48 weeks in the 12mg group

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