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That suggests GLP-1s might help symptoms surrounding lipedema, such as: Improved mobility Less systemic inflammation Reduced stress on joints Better blood sugar and insulin regulation However GLP-1 has not been shown to remove lipedema fat Women may see weight loss everywhere except their legs, which can ironically make lipedema more obvious

By late 2025, it had been updated again, to include effects such as intestinal obstruction and severe constipation including fecal impaction, among several other additions

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GLP-1 medications qualify if prescribed for an IRS-recognized condition: obesity (BMI 30), type 2 diabetes, or established cardiovascular disease

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Neurodegeneration in amyotrophic lateral sclerosis: the role of oxidative stress and altered homeostasis of metals