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Oxidative stress (formulated in Harman's free radical theory of aging) is also thought to contribute to the process
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The anatomical distribution of GLP-1R throughout the reproductive system and several preclinical evidence support that GLP-1 can modulate the HPG axis activity at different levels, thus connecting reproductive functions, metabolic system, nutrition, and energy homeostasis mechanisms
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They also play essential roles in reactions to chemical stimuli and stress (190)
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