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While preclinical models have yielded valuable insights into microglial heterogeneity, many markers defined in rodent systems [e.g., arginase 1 (Arg1) or rodent-specific chitinase-like protein (Ym1)] have limited expression or different regulation in human microglia
Research models frequently examine GHK-Cu for its interactions with growth factor signaling, extracellular matrix regulation, and gene expression pathways influenced by copper availability
However, in the PCA of the MD holo structure, the weak points in the graphs appear in the first 3 components for replicates 1 and 2, but they appear in the first 2 components for replicate 3 (S3 Fig)
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