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Some patients may wish to take a "drug holiday" after extended treatment, though the evidence supporting this approach is limited, and the risks of weight regain should be thoroughly discussed

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Inhibition of estrone sulfatase in human liver microsomes by quercetin and other flavonoids

Even persistent nausea, which does not directly cause fluid loss, leads to reduced water intake because the last thing a nauseated person wants to do is drink

We suggest a commitment to the program for at least three months to achieve the most beneficial outcome