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In the Phase 2 trial published in the New England Journal of Medicine, participants receiving the highest dose of retatrutide (12mg weekly) achieved a mean body weight reduction of 24.2% over 48 weeks

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The research and clinical experience point toward morning dosing for most people, but the reasoning involves more than habit

With the weekly regimens, in some cases, the daily dose may exceed the 5mg/kg/day limit, but the weekly dose does not exceed 35mg/kg/week, the creators explain

Semaglutide is the active ingredient in three FDA-approved medications