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In addition, the stimulation of GPX4 protein synthesis was enhanced through the mTOR/eIF4E axis [84,85]
By incorporating potent components like glutathione, a natural antioxidant, into their formulation, these capsules effectively combat melanin production, leading to a gradual reduction in dark spots and hyperpigmentation
doi: 10.7314/APJCP.2014.15.5.2329 87 RenBLuoSTianXJiangZZouGXuFet al
Importantly, it iswell-known that when glutathione or cysteine is addedto melanocytes or melanoma cell lines, the melanogeneticpathway is shifted from eumelanin towardspheomelanin formation.After oral dosing, glutathione is not well absorbedfrom the gastrointestinal tract and intravenousadministration has thus been used in many counties,especially in southeast Asia
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