CJC-1295 without DAC usually requires daily injections, while CJC-1295 with DAC, due to its extended half-life, is often dosed once or twice a week
Lack of systemic metabolic regulation The energy generated from the oxidation of fatty acids needs to be fully dissipated through systemic metabolism throughout the human body
Hadrup N, Loeschner K, Skov K, Ravn-Haren G, Larsen EH, Mortensen A et al (2016) Effects of 14-day oral low dose selenium nanoparticles and selenite in rat-as determined by metabolite pattern determination
500 mg Other Ingredients: Vegetarian capsule (hypromellose and water), ascorbyl palmitate, microcrystalline cellulose, L-leucine, and silica
PMID: 32578044
Cagrilintide is engineered around that problem: it is a modified, lipidated peptide that acts as a dual amylin and calcitonin receptor agonist and is stable enough for once-weekly subcutaneous dosing