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Depending on the individual, monthly injections of B12 may be sufficient for some, while others may need more frequent doses

It is typically prescribed to relieve moderate-to-severe menopausal vasomotor symptoms, treat hypoestrogenism due to ovarian insufficiency, and support feminizing hormone therapy regimens under clinician supervision

If you are below 30, supplementation of 2,000 to 5,000 IU daily (depending on your starting level) can meaningfully improve energy within 4 to 6 weeks

Additional trials are also underway in participants with type 1 diabetes targeting diverse pathways including oxidative stress, using nicotinamide adenine dinucleotide phosphate oxidase (Nox)-1/4 inhibitors, and the nuclear factor erythroid 2-related factor 2 (Nrf2) pathway, using bardoxolone (NCT03366337, NCT03550443) [84, 85]