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This schedule aligns with British practice, reflecting the longer duration of action of hydroxocobalamin
It inhibits NNMT (nicotinamide N-methyltransferase), an enzyme regulating metabolism, fat storage, and NAD+ consumption.[4][27][6] NNMT methylates nicotinamide, a NAD+ breakdown product, diverting it from recycling and reducing available NAD+
[7] Use is also contraindicated in patients with arterial bleeding
Heavy NNMT activity means less NAD+ salvage, lower NAD+ pools, and reduced sirtuin activity
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B12 shots deposit cobalamin into muscle tissue, where it releases gradually into the bloodstream over hours to days
Rare but Serious Complications Even though rare, serious problems can happen with Vitamin B12 shots
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