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DOI: org/10.1016/j.bbrc.2003.09.086 34

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Thus, since only the OPRT C92 homodimer is active, random exchange of subunits of an active OPRT C92 dimer and iOPRT C44 variant would result in a time-dependent decrease of activity, reaching 50% of initial activity when the two different modified subunits are randomly mixed in the absence of disulfide bond formation

The supplement works best when taken before exercise since it enhances fat oxidation during workouts