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PMID: 8 ArrudaA
Class B GPCRs, including GLP-1R, are activated by endogenous peptide hormones, and the development of small-molecule agonists of these receptors has proven particularly challenging ( 14 )
Cohort studies have also reported an association between semaglutides and neuropathy in patients with diabetes, although causality remains debated and the absolute risks are low
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