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7.3 Translational potential Research on macrophage polarization has revealed its central role in disease pathogenesis, providing a foundation for phenotype-targeted therapeutic strategies and demonstrating considerable potential for context-directed personalized medicine
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Preclinical and clinical studies have uncovered several gastrointestinal effects of metformin, including stimulation of the incretin hormone glucagon-like peptide-1 (GLP-1) [8], slowing of gastric emptying [8], suppression of intestinal glucose absorption [9], inhibition of bile acid resorption [10, 11] and modulation of the gut microbiota [12]
The exposure of semaglutide decreases with an increase in body weight
On January 25, 2010, the FDA approved Novo Nordisk's liraglutide (Victoza )
Tan, X., van Egmond, L., Chapman, C
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