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In parallel, oxidative stress contributes to pathogenesis through an imbalance between pro-oxidant and antioxidant systems, promoting cellular injury and immune dysfunction

Mancias JD, Wang X, Gygi SP, Harper JW, Kimmelman AC

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NICOTINAMIDE (NAM), NAD+ PRECURSOR: The NAMPT salvage pathway that converts nicotinamide to NAD+ represents the major route to NAD+ biosynthesis in mammals