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Additionally, in gastric cancer, tanshinone IIA significantly activates lipid peroxidation and downregulates the expression of SLC7A11 by regulating p53 (Guan et al., 2020), leading to ferroptosis and decreased cell stemness (Ni et al., 2022)
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Similarly, animals with deficiencies in indirect scavengers of ROS, such as sulfiredoxin and metallothionein, are highly susceptible to alcohol-induced hepatic injury 27,31