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Recent investigations have focused more on combination therapies, particularly pairing glutathione with its precursors (l-cystine, cysteine peptides) or other antioxidants (vitamin C, alpha-lipoic acid, zinc), reflecting the understanding that synergistic effects may enhance skin-lightening outcomes
Tirzepatide, with its synergistic central mechanism, holds promise for potentially overcoming some of this heterogeneity and achieving greater efficacy
Individual factors, including the severity of underlying metabolic dysfunction, lifestyle modification sustainability, and weight loss magnitude, influence whether long term treatment remains necessary
10.1056/NEJMoa1607141 65 MarsoS
10.1038/oby.2005.205 Obes
Helvacioglu, F., Yeter, C., Sencan, S., Tunc, Z
