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The severity of colon mucosal damage was evaluated using the colonic mucosal damage index (CMDI) following the criteria outlined by 2.6 H&E and AB-PAS staining Paraffin-embedded colonic tissue blocks were cut into 4-m-thick sections for H&E staining (Table 2
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Furthermore, chronic overproduction of TGF1 from astrocytes and microglia leads to decreased pericyte coverage, facilitating vascular remodeling and suboptimal brain perfusion [187,188,189]
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However, same effect was not observed for HDRS somatic anxiety item (#13) (Table S11,S12)
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