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These findings suggest that Gstp1 expression is slightly affected by the suppression of YTHDF2-mediated mRNA degradation, indicating that YTHDF2 fine-tunes Gstp1 levels during the PNT
Thus, at least four studies that fulfilled the criteria of evidence based-medicine (randomized study, systematic review) supported the efficacy of oral vitamin B12 therapy [21-24]
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However, in rare casessuch as patients with kidney disease or specific hereditary disorders related to vitamin B12 metabolismhigh doses or inappropriate use could potentially cause complications
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