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The STEP 1 trial (Wilding et al., NEJM 2021) demonstrated an average 14.9% body weight reduction with semaglutide 2.4mg weekly over 68 weeks, compared to 2.4% with placebo a magnitude of effect that no prior anti-obesity medication had achieved

We talk honestly about realistic, individualized goals rather than a single target weight

To address this limitation, various long-acting GLP-1 analogues have been developed, designed to prolong in vivo efficacy and enhance therapeutic potential (Table 1)

Semaglutide directly activates GLP-1 receptors in the brain and gut, triggering strong signals of fullness and reduced hunger within hours

During the docking simulations, the rotational bands of the ligands were explicitly considered as flexible, and the receptor was treated as a rigid body

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