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44 Like the NTD, the CTD (AA residues 357393) is an unstructured region that plays critical roles in several processes, including cofactor recruitment, nonspecific DNA binding, protein stability, and the regulation of subcellular location

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6 Multi-agonist strategies are increasingly being studied, some of which include dual GLP-1/GIP agonists like tirzepatide and triple agonists that target GLP-1, GIP, and glucagon-like retatrutide