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Considering our findings, we hypothesise that a mechanism of rescue could be the reduction of the natural propensity for CBS to polymerise which could reduce one pathway towards aggregation (Fig

observed that Trx2 levels are high in some mutants defective in Grx1 function and that Grx1 levels are high in other mutants lacking Trx2 (Potamitou et al., 2002)

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Significant and measurable weight loss is usually seen after a few months of consistent use, with the most substantial results becoming apparent over a period of 6 months to a year

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A reduction in proliferation, NF-B activation, migration, invasion, migration, colony formation, Cyclin D1, p-Akt, ERK-MAPK pathway, cAMP, and GSK3 accompanied this increase (Table 1)