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Although oxidative stress was defined originally as a balance between oxidants and antioxidants systems, an equilibrium among antioxidant strategies is needed to avoid the generation of oxidants and ROS (Mari et al., 2010)

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The renal or extrarenal expression of 1--hydroxylase (CYP27B1) enzymatic action converts 25(OH)VD 3 to an active metabolite 1,25-dihydroxy vitamin D 3 (1,25(OH) 2 VD 3) 13