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The screening identified six key pharmacophoric features in the co-crystallized structure of PDE10A (PDB ID: 5UWF) and the ligand 16d, which included one hydrogen bond acceptors (HBA) interacting with Q726, an aromatic ring (AR) represented by the thiophene moiety, and four hydrophobic areas (HA) represented by phenol, sulfide, and fluorine groups
Nrf2 enhances resistance of cancer cells to chemotherapeutic drugs, the dark side of Nrf2
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GSH is synthesized intracellularly from its amino acid precursors by the ATP-requiring cytosolic enzymes -glutamylcysteine synthetase (GSH1) and by GSH synthetase (GSH2)