95% CI, 10.9 to 8.5), as did BMI (mean difference, 4.7
In a previous work, using cellular models derived from PKAN patients, we confirmed the hypothesis that CoA deficiency caused by PANK2 mutations affects the expression levels and activity of key mitochondrial proteins harboring a 4-phosphopantetheinyl cofactor such as mtACP, ALDH1L2 or AASS [12]
Another thing to consider is wich brand of hydroxycobalamin you use
responses vary with receptor subtype, concentration, exposure time and model
[PubMed] Hathaway CK, Agarwal N, Planas LG, et al
While both medications have their unique benefits, using them at the same time could affect how each works in the body, including the possibility of increased side effects