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Randomized double blind trial of an extract from the pentacyclic alkaloid-chemotype of uncaria tomentosa for the treatment of rheumatoid arthritis

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Despite promising preclinical results with inhibitors (e.g., ferrostatin-1) and gene therapies targeting GPX4/ACSL4, clinical translation faces critical barriers: the poorly defined temporal dynamics of ferroptosis post-stroke hinders therapeutic window optimization, and its interplay with necroptosis/pyroptosis requires clarification to guide combination therapies

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Ostrem, B., Di Lullo, E

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