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In many types of SCD disorders with impaired fatty acid metabolism, excessive acylcarnitines can build up
doi: 10.1016/j.repbio.2022.100607 208 BaldiniCMoriconiFRGalimbertiSLibbyPDe CaterinaR
People who have not seen success with other weight loss medications or treatments
Most genetic diseases associated with PDHc deficiency are due to mutations in either of the two subunits ( encoded by the PDHA1 gene or encoded by the PDHB gene) of the functional PDH heterotetramer of the PDHc
This vicious cycle of OS and mitochondrial dysfunction is associated with the activation of apoptotic pathways, including the upregulation of pro-apoptotic proteins like Bax and the downregulation of anti-apoptotic proteins like Bcl-2 (Zhu et al., 2023
(2) reduce clearance rate due to slowed metabolism and renal filtration (131)
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