These effects are usually mild to moderate and diminish over time
After propensity score matching (18,386 patients), researchers found: Patients receiving tirzepatide were 1.76 times more likely to achieve 5% weight loss 2.54 times more likely to achieve 10% weight loss 3.24 times more likely to achieve 15% weight loss At 12 months, the difference in weight change was 6.9 percentage points favoring tirzepatide
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The weight of evidence supports a role in dementia risk reduction, particularly among individuals with diabetes, obesity, metabolic syndrome, or APOE 4 risk
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79 We estimate that the net proceeds from this offering will be approximately $179.1 million, or approximately $206.8 million if the underwriters exercise their option to purchase additional shares of our common stock in full, based upon the initial public offering price of $18.00 per share, after deducting the underwriting discounts and commissions and estimated offering expenses payable by us