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CoA-LOT: BN250510/CA
Innate Repair Receptor (IRR) Activation: ARA-290 binds selectively to the IRR (EPOR/CR heteromer), activating the full IRR-mediated tissue protection cascade: JAK2/STAT3, PI3K/Akt, and MAPK/ERK signalling, producing anti-apoptotic, anti-inflammatory, and regenerative downstream effects across neural, vascular, and metabolic cell types
Loren Pickart Pickart, Loren a world- renowned biochemist known for his significant contributions to the field of skin biology and aging, has passed away at the age of 85
Cite: Coleman, Y
Nature , 530(7589), 184-189
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