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You should contact your GP if you experience: Weight loss that is faster than expected or causing functional problems Signs of malnutrition Extreme fatigue, hair loss, brittle nails, persistent dizziness, or difficulty concentrating may suggest inadequate nutritional intake Muscle weakness or difficulty with daily activities Significant loss of muscle mass can impair function and increase fall risk, particularly in older adults Skin changes beyond sagging Rashes, persistent redness, breakdown, or infection in skin folds require assessment Psychological distress If body image concerns are affecting your mental health, quality of life, or medication adherence, support is available Seek urgent medical advice if you develop: Severe, persistent abdominal pain (which could indicate pancreatitis) Persistent vomiting or signs of dehydration Symptoms of gallstones (pain in upper right abdomen, nausea) Signs of kidney problems (reduced urination, swelling, fatigue) Your GP can assess whether your weight loss trajectory is appropriate for your individual circumstances and may refer you to a dietitian for nutritional optimisation or to physiotherapy for exercise guidance

But this means were sort of working with observational data

GLP-1 receptors are found throughout the body, including in adipose tissue, though their direct metabolic effects on fat cells in humans remain an area of active investigation

2022;186:R93-111

Patients with known risk factors for liver diseasesuch as obesity, diabetes, excessive alcohol use, or a family history of liver conditionsshould be proactive about liver health screening

Ive proven to myself I need it. For patients who do get off the drugs, they tend to gain two thirds of their lost weight back, according to research by Ozempic maker Novo Nordisk