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(2009) Activation of the GH/IGF-1 axis by CJC-1295, a long-acting GHRH analog, results in serum protein profile changes in normal adult subjects, Growth Horm IGF Res, 19(6), pp
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However, BPC-157 has never completed human clinical trials, so its safety profile in humans is unknown
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The more accurate concern is that rapid weight loss, reduced lean mass, and decreased mechanical loading may create bone health concerns in some populations, particularly when resistance training is absent
A Brief History of GH Secretagogues The GH secretagogue story begins in the 1970s when Cyril Bowers discovered that small synthetic peptides based on enkephalin could release GH from pituitary cells without acting through opioid receptors
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