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Collectively, these findings indicate a bidirectional enhancement of -syn aggregation and ferroptosis, driving dopaminergic neuron deterioration

LOX enzyme catalyzes the oxidative deamination of telopeptide lysine/hydrolysine residues to yield highly reactive aldehydes that further react to form immature and then mature permanent cross-links 16,17

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Wang SY, Fu XX, Duan R, Wei B, Cao HM, Yan E, et al