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In the peripheral system, GLP-1R mediates the actions of GLP-1 via the incretin axis, in which stimulation of the GLP-1R with GLP-1 primarily triggers insulin release from islet cells in a glucose-dependent manner and inhibits glucagon secretion from islet cells (110)
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Patients on 7 days per month metronidazole therapy had normalized TMAO levels (PAT12-14), whereas two patients on 5 days per month metronidazole therapy had extreme TMAO elevations (PAT 17-18) suggesting that the duration of antibiotic therapy may impact microbial l-carnitine degradation (Table 1)
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