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Ensuite, grce l'action catalytique de la GR, le GSSG est rduit en GSH, obtenant ainsi sa rgnration et son effet antioxydant durable

& Vermeulen, N

Endocrinology 158 (6), 17011714

Clinical trials vs real-world results What the clinical trials show The landmark SURMOUNT-5 trial published in 2025 compared these medications directly at standard maximum doses: 1 Mounjaro (tirzepatide 15 mg) produced 20.2% average weight loss Wegovy (semaglutide 2.4 mg) produced 13.7% average weight loss The 6.5 percentage point difference was statistically significant This trial used the maximum approved doses at the time (Mounjaro 15 mg, Wegovy 2.4 mg) and lasted 72 weeks

M.RomanelliM.MargolisD.KappS.et al (2022)

This is why many clinicians recommend: Gradual dose reductions Close monitoring of hunger and weight trends Adjustments based on real-world response Stopping suddenly is more likely to result in regain than a guided transition