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Serum concentrations of melatonin are typically between 80 and 120 pg/mL at night, peaking between 2:00 and 4:00 A.M

1.1 mg in nonpregnant women) and riboflavin likewise increases to 1.4 mg/day

2019 Jun;11(6):804-812

Pryor, J

doi: 10.1126/scitranslmed.aay8071

Targeted Support for Melasma and Hyperpigmentation Melasma causes dark patches to form across the face, typically on the nose, cheeks, forehead, and chin, when melanin levels rise above normal