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News provided by Eli Lilly and Company May 21, 2026, 06:45 ET In TRIUMPH-1, participants on 12 mg retatrutide lost an average of 70.3 lbs (28.3%) over 80 weeks with 45.3% of participants achieving 30% weight loss, a level long associated with bariatric surgery Individuals with a baseline BMI 35 who participated in a study extension continued to lose weight, and achieved up to an average of 85.0 lbs (30.3%) weight loss at 104 weeks At the 4 mg dose, reached with only a single escalation step, participants lost an average of 47.2 lbs (19.0%) at 80 weeks with a lower observed discontinuation rate due to adverse events vs
Metformin should be temporarily stopped during acute illness, severe dehydration, or before procedures requiring iodinated contrast media, and restarted only when renal function is stable
This modern therapy may reduce body weight, lower waist measurements, help regulate blood pressure, stabilize blood sugar, and lessen inflammation
All of these weight loss medications are regulated and must be prescribed or authorised by a healthcare professional
[Abstract]2025 Jan 1;21(2):725-744
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